ERU flares should be treated aggressively with topical ophthalmic corticosteroids and system non-steroidal anti-inflammatory medications. The goals for medical treatment of ERU are to reduce pain and inflammation and to preserve vision. Anterior uveitis or equine recurrent uveitis (ERU) is the most-common cause of blindness in the horse. Prednisolone acetate is used to treat anterior uveitis in the horse. ![]() It is the preferred orticosteroid for treatment of anterior uveitis in small animals due to the superior penetration in the anterior chamber when compared to dexamethasone. Prednisolone acetate is used in non-ulcerative corneal disorders, including chronic superficial keratitis of dogs, and feline eosinophilic keratitis. Prednisolone acetate is used in a wide variety of inflammatory conditions of the sclera and episclera, including scleritis, episcleritis, ocular nodular fasciitis, nodular granulomatous episclerokeratitis, proliferative keratoconjunctivitis of collies, and fibrous histiocytoma. Prednisolone acetate is a liquid suspension which may be administered directly or through a sub-palpebral catheter. Dexamethasone is a more potent corticosteroid than prednisolone acetate, but prednisolone acetate has superior penetration into the anterior chamber. Prednisolone acetate has approximately four times the anti-inflammatory potency of cortisone. When choosing among ophthalmic corticosteroids, consideration should be given to relative potency, penetration, ease, and frequency of application. Disorders of the posterior chamber and the eyelid are generally treated with systemic corticosteroids, as topical ophthalmic corticosteroids do not penetrate these structures adequately. Topical corticosteroids are used to treat inflammatory processes of the sclera, conjunctiva, cornea, and anterior chamber. This monograph discuses the ophthalmic use of prednisolone acetate. Prednisolone is a synthetic corticosteroid that may be used systemically or topically.
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